Table 2.
Differentially expressed microRNAs in retinal cell types.
| MicroRNA | Regulation/function | Retinal cell type | Refs |
|---|---|---|---|
| miR-204, miR-211 | Upregulated | RPE | [48] |
| miR-23a | Upregulated (in healthy cells) Downregulated (in AMD) |
RPE | [49] |
| miR-183/96/182 | Downregulated in dark Upregulated in light |
Photoreceptors and interneurons of the inner nuclear layer | [36] |
| miR-29b | Upregulated after streptozotocin (STZ) injection; upregulation protects against apoptosis | RGCs and cells of the INL | [47] |
| mir-133b | Overexpression suppresses maturation and function of dopaminergic amacrine cells | Dopaminergic amacrine cells | [46] |
| mir-124 | Abundantly expressed in differentiated neurons | All retinal cell layers, but is not detected in the RPE | [45] |
| miR-155*, miR-124. |
Resting microglia: low expression of miR-155 and high expression of miR-124 Activation phenotype (M1): downregulation of miR-124, upregulation of miR-155 Activation phenotype (M2): upregulation of miR-124, downregulation of miR-155 |
Microglia | [52] |
*Expression of these miRNAs has been reported for microglia of the brain.