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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: J Invest Dermatol. 2013 Mar 25;133(11):2530–2537. doi: 10.1038/jid.2013.151

Figure 6. Schematic model of the role of CXCR4 and CXCL12 in IL-22-mediated keratinocyte proliferation.

Figure 6

A schematic model for IL-22, CXCL12, and SOCS3 regulation of KC proliferation is shown. JAK/STAT3 pathway is activated by IL-22 and results in modest upregulation of SOCS3 that is insufficient to downregulate keratinocyte proliferation (A). SOCS3 expression, however, is synergistically upregulated in the presence of IL-22, CXCR4, and CXCL12 (B), resulting in the abrogation of STAT3 signaling and marked inhibition of keratinocyte proliferation.