Table 1.
Baseline trabecular bone microstructure and stiffness measures and their % changes (mean±SD) over baseline after 12 days of treatment.
| Baseline | % Changes in 12 days over baseline | ||||
|---|---|---|---|---|---|
| VEH | ALN | PTH | PTH+ALN | ||
| BV/TV | 0.31±0.07 | 5.7±8.7 % | 12.5±3.2 % | 32.5±15.3 % | 45.1±18.5 % |
| Tb.N* (1/mm) | 5.9±0.7 | −2.2±5.5 % | 1.0±1.4 % | −2.6±8.5 % | 1.26±5.5 % |
| Tb.Th* (mm) | 0.069±0.008 | 8.5±6.3 % | 9.8±1.5 % | 35.4±9.6 % | 34.9±14.2 % |
| Tb.Sp* (mm) | 0.15±0.02 | 2.4±3.9 % | −1.9±1.4 % | 2.5±7.3 % | −6.2±3.9 % |
| SMI | 1.2±0.6 | −0.9±6.0 % | −6.4±2.6 % | −14.6±7.5 % | −26.6±9.0 % |
| Conn.D (1/mm3) | 194±46 | −8.5±12.2 % | −4.1±9.6 % | −18.6±14.4 % | −16.3±19.9 % |
| Tb.Stiff (kN/mm) | 82±42 | 9.2±24.6 % | 24.0±13.4 % | 68.5±32.5 % | 102.8±50.8 % |
Significant % changes over baseline are given in bold. Baseline measures are from pooled data of all treatment groups. All parameters were not significantly different among treatment groups at baseline.