Table 1.
Clinical characteristics of pediatric and adult subjects at the time of the first positive nontuberculous mycobacteria culture with cystic fibrosis center comparisons for patients without positive nontuberculous mycobacteria cultures from 2005
| Subject Characteristics | Pediatric Subjects |
Adult Subjects |
||||
|---|---|---|---|---|---|---|
| Positive NTM (n = 48) | 2005 Pediatric CF Center, Negative NTM (n = 451) | Positive NTM vs. Negative NTM | Positive NTM (n = 48) | 2005 Adult CF Center, Negative NTM (n = 103) | Positive NTM vs. Negative NTM | |
| Age, median yr (IQR) | 12.9 (11.4–14.5) | 11.2 (6.0–17.1) | P = 0.16 | 26.4 (21.0–34.2) | 32.3 (25.6–39.8) | P < 0.01* |
| Female sex, n (%) | 24 (50) | 216 (48) | P = 0.78 | 27 (56) | 61 (59) | P = 0.73 |
| FEV1% predicted, mean (SD) | 89% (19.6) | 88% (23.8) | P = 0.66 | 71% (22.0) | 58% (23.7) | P < 0.01* |
| Pediatric BMI percentile, median (IQR) | 29.5th (12.0–53.0) | 40.9th (21.5–63.4) | P = 0.02* | — | — | |
| Adult BMI, median (IQR) | — | — | 21.3 (19.1–24.1) | 21.0 (19.0–23.8) | P = 0.06 | |
| Azithromycin use, n (%) | 15 (31) | N/A | N/A | 18 (38) | N/A | N/A |
| Macrolide resistant NTM, n (%) | 4 (8) | 7 (15) | ||||
| CF genotype, n (%) | P = 0.24 | P = 0.01* | ||||
| F508del homozygous | 29 (61) | 221 (49) | 20 (42) | 50 (49) | ||
| F508del heterozygous | 15 (31) | 159 (35) | 25 (52) | 43 (42) | ||
| Other | 4 (8) | 45 (10) | 3 (6) | 6 (6) | ||
| Unknown | 0 (0) | 26 (6) | 0 (0) | 4 (4) | ||
| Coinfection, n (%) | ||||||
| Staphylococcus aureus (any) | 35 (73) | 296 (69) | P = 0.30 | 34 (72) | 47 (51) | P < 0.01* |
| Pseudomonas aeruginosa (any) | 16 (33) | 174 (41) | P = 0.47 | 26 (55) | 67 (73) | P = 0.20 |
| Stenotrophomonas maltophilia | 14 (29) | 49 (12) | P < 0.001* | 10 (21) | 8 (9) | P = 0.02* |
| Aspergillus fumigatus | 18 (38) | 72 (17) | P < 0.001* | 14 (30) | 7 (8) | P < 0.001* |
| NTM type isolated, n (%): | ||||||
| MAC | 36 (75) | N/A | N/A | 33 (69) | N/A | N/A |
| M. abscessus | 10 (21) | 13 (27) | ||||
| MAC and M. abscessus | 1 (2) | 0 (0) | ||||
| Other | 1 (2) | 2 (4) | ||||
Definition of abbreviations: BMI = body mass index; IQR = interquartile range; MAC = Mycobacterium avium complex; N/A = not available; NTM = nontuberculous mycobacteria
*
Statistically significant correlations.