Table 3.

Estimates of the differences in FEV₁ % predicted and Wisconsin chest X-ray, using multivariable generalized estimating equation models with independent working correlation structures, adjusted for other significant risk factors for progression of lung disease

	FEV1 % Predicted		WCXR Score
Risk Factor	Difference (SE)	P Value	Difference (SE)	P Value
Age, yr	−0.75 (0.19)	<0.001	1.34 (0.14)	<0.001
Genotype (Ref: Any CFTR class IV or V)
F508del/F508del	−5.26 (3.55)	0.1	4.81 (1.59)	0.002
F508del/any CFTR class I–III	−10.59 (4.03)	0.009	6.26 (2.14)	0.004
BMI for age < 10th percentile	−15.75 (4.78)	0.001	13.19 (5.11)	0.01
Recent hospitalization*	−9.57 (2.36)	<0.001	5.87 (1.16)	<0.001
Meconium ileus	−6.62 (2.85)	0.02	−0.36 (1.80)	0.8
Mucoid P. aeruginosa, ever-positive respiratory culture	−4.45 (2.43)	0.07	4.96 (1.79)	0.006

Definition of abbreviations: BMI = body mass index; CFTR = cystic fibrosis transmembrane conductance regulator; WCXR = Wisconsin chest X-ray.

^*Any hospitalizations within the 6 months before a measurement of FEV₁ or the same age as WCXR.