Table 1.

Novel loci reaching genome-wide significance (P < 5 × 10^-8) for the tails of anthropometric traits and clinical classes of obesity

							Stage 1				Stage 2*				Stage 1 + Stage 2
SNP	Chr	Position	Nearby gene	Effect allele	Other allele	Effect allele freq	No. cases	No. controls	OR	P	No. cases	No. controls	OR	P	No. cases	No. controls	OR	P
Height tails
rs584438	17	35852698	IGFBP4	c	a	0.617	7830	7850	1.18	1.11E-09	1814	1814	1.19	0.001	9644	9664	1.18	5.22E-12
rs6662509	1	9240191	H6PD	t	c	0.1463	5462	5461	1.23	2.21E-06	3615	3566	1.23	3.37E-05	9077	9027	1.23	3.19E-10
rs2362965	3	159592073	RSRC1/SHOX2	t	a	0.50	7989	7993	1.14	1.45E-07	4819	4775	1.10	0.002	12808	12768	1.12	2.14E-09
rs1594829	8	26261994	PPP2R2A	c	t	0.7688	6693	6697	1.18	5.51E-07	4166	4115	1.11	0.01	10859	10812	1.15	3.88E-08
Obesity Class 2
rs7989336	13	95815549	HS6ST3	a	g	0.4704	9825	62114	1.12	5.88E-09	1664	17113	1.04	0.25	11489	79226	1.10	1.06E-08
rs17381664	1	77820919	ZZZ3	c	t	0.3923	9833	62114	1.11	7.61E-08	5351	33841	1.05	0.04	15184	95955	1.09	2.85E-08
Obesity Class 1
rs17024258	1	109948844	GNAT2	t	c	0.0364	18662	38427	1.23	1.41E-06	8956	15471	1.28	1.12E-06	27618	53898	1.25	8.66E-12
rs4735692	8	76778218	HNF4G	a	g	0.5834	32675	65697	1.07	5.03E-08	22086	38352	1.04	0.005	54761	104049	1.06	2.48E-09
rs13041126	20	50526403	MRPS33P4	t	c	0.7179	32020	64015	1.07	3.05E-07	22088	37595	1.04	0.007	54108	101610	1.06	2.16E-08
rs2531995	16	3953468	ADCY9	t	c	0.6146	32433	65542	1.06	3.17E-06	6680	16602	1.07	0.004	39113	82144	1.07	4.04E-08
Overweight
rs4735692	8	76778218	HNF4G	a	g	0.5839	92703	65698	1.05	6.13E-09	65323	39290	1.03	0.003	158026	104988	1.04	3.51E-10
rs7503807	17	76205706	RPTOR	a	c	0.5654	92855	65723	1.04	4.20E-06	64535	38813	1.03	0.0009	157390	104536	1.04	1.98E-08

^*Stage 2 consists of studies with either GWAS and Metabochip data. Not all SNPs were present on Metabochip.