Table 2.
Association results for novel genome-wide significant (P < 5 × 10-8) SNPs with height and obesity-related traits
SNP | Gene | Effect allele |
Other allele |
BMI tails | Obesity class 3 | Obesity class 2 | Obesity class 1 | Overweight | BMI (continuous)a |
Height tails | Height (continuous)a |
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---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| |||||||||||||||||||
OR | P | OR | P | OR | P | OR | P | OR | P | Effect | P-value | OR | P | Effect | P-value | ||||
Height tails
| |||||||||||||||||||
rs584438 | IGFBP4 | c | a | 0.98 | 0.52 | 1.02 | 0.64 | 1.01 | 0.47 | 1.00 | 0.75 | 1.00 | 0.59 | 0.005 | 0.22 | 1.18 | 5.22E-12 | 0.025 | 9.43E-11 |
rs6662509 | H6PD | t | c | 1.00 | 0.95 | 1.11 | 0.07 | 1.01 | 0.83 | 0.99 | 0.34 | 0.99 | 0.35 | -0.006 | 0.27 | 1.23 | 3.19E-10 | 0.031 | 7.76E-12 |
rs2362965 | RSRC1/SHOX2 | t | a | 0.95 | 0.02 | 0.97 | 0.25 | 0.98 | 0.20 | 0.99 | 0.37 | 0.99 | 0.21 | -0.007 | 0.05 | 1.12 | 2.14E-09 | 0.017 | 7.07E-08 |
rs1594829 | PPP2R2A | c | t | 1.03 | 0.33 | 1.06 | 0.11 | 1.01 | 0.58 | 1.00 | 0.82 | 1.01 | 0.32 | 0.004 | 0.33 | 1.15 | 3.88E-08 | 0.016 | 4.29E-05 |
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Obesity Class 2
| |||||||||||||||||||
rs7989336 | HS6ST3 | a | g | 1.09 | 0.0001 | 1.11 | 0.0006 | 1.10 | 1.06E-08 | 1.04 | 9.38E-05 | 1.04 | 2.33E-06 | 0.016 | 8.80E-06 | 1.00 | 0.89 | -0.001 | 0.71 |
rs17381664 | ZZZ3 | c | t | 1.08 | 0.0001 | 1.12 | 5.41E-05 | 1.09 | 2.85E-08 | 1.05 | 6.80E-08 | 1.04 | 2.23E-07 | 0.022 | 2.50E-11 | 1.06 | 0.005 | 0.010 | 0.004 |
| |||||||||||||||||||
Obesity Class 1
| |||||||||||||||||||
rs17024258 | GNAT2 | t | c | 1.27 | 0.02 | 1.45 | 0.002 | 1.26 | 7.73E-05 | 1.25 | 8.66E-12 | 1.13 | 1.41E-08 | 0.067 | 4.34E-14 | 1.21 | 0.08 | 0.010 | 0.36 |
rs4735692 | HNF4G | a | g | 1.09 | 1.97E-05 | 1.08 | 0.006 | 1.05 | 0.0005 | 1.06 | 2.48E-09 | 1.04 | 3.51E-10 | 0.019 | 9.94E-10 | 1.02 | 0.50 | 0.006 | 0.10 |
rs13041126 | MRPS33P4 | t | c | 1.08 | 0.001 | 1.05 | 0.16 | 1.06 | 0.0002 | 1.06 | 2.16E-08 | 1.04 | 1.43E-06 | 0.017 | 8.52E-07 | 1.02 | 0.56 | 0.002 | 0.65 |
rs2531995 | ADCY9 | t | c | 1.06 | 0.01 | 1.09 | 0.006 | 1.06 | 0.001 | 1.07 | 4.04E-08 | 1.03 | 5.57E-05 | 0.021 | 6.58E-08 | 1.07 | 0.005 | 0.018 | 1.87E-06 |
| |||||||||||||||||||
Overweight
| |||||||||||||||||||
rs4735692 | HNF4G | a | g | 1.09 | 1.97E-05 | 1.08 | 0.006 | 1.05 | 0.0005 | 1.06 | 2.48E-09 | 1.04 | 3.51E-10 | 0.019 | 9.94E-10 | 1.02 | 0.50 | 0.006 | 0.10 |
rs7503807 | RPTOR | a | c | 1.08 | 7.07E-05 | 1.13 | 9.44E-06 | 1.07 | 2.46E-06 | 1.05 | 1.12E-07 | 1.04 | 1.98E-08 | 0.020 | 3.00E-10 | 0.99 | 0.55 | -0.001 | 0.85 |
The beta represents the difference in standardized effects.