Table 3. Daily urine volume, fluid intake, and free water clearance by CrCL group.
| Parametera | CrCL <30 ml/min (N=12) | CrCL 30–60 ml/min (N=12) | CrCL >60 ml/min (N=12) |
|---|---|---|---|
| Urine volume (ml) | |||
| Baseline, day 0 | 2099 (806) | 1949 (586) | 2644 (897) |
| 0–24 h after dosing | 3189 (850) | 4654 (1504) | 6891 (1571) |
| Change from baseline | 1090 (785) | 2705 (1375) | 4247 (1673) |
| 24–48 h after dosing | 2636 (850) | 2462 (1038) | 2259 (1186) |
| Change from baseline | 537 (732) | 513 (789) | −385 (755) |
| Fluid intake (ml) | |||
| Baseline, day 0 | 2254 (662) | 2162 (374) | 2332 (753) |
| 0–24 h after dosing | 2815 (682) | 2998 (578) | 4726 (1182) |
| Change from baseline | 560 (800) | 836 (416) | 2393 (1137) |
| 24–48 h after dosing | 2555 (708) | 2467 (574) | 2628 (1315) |
| Change from baseline | 300 (769) | 304 (452) | 296 (1031) |
| Free water clearance (ml/min) | |||
| Baseline, day 0 | 0.0 (0.5) | −0.6 (0.5) | −0.3 (0.7) |
| 0–24 h after dosing | 0.9 (0.5) | 1.3 (1.0) | 2.4 (0.8) |
| Change from baseline | 0.9 (0.6) | 1.9 (0.9) | 2.7 (1.0) |
| 24–48 h after dosing | 0.5 (0.4) | −0.3 (0.8) | −0.3 (0.7) |
| Change from baseline | 0.5 (0.5) | 0.4 (0.4) | 0.0 (0.6) |
Abbreviation: CrCL, creatinine clearance.
a
Values are mean (±s.d.).