Figure 6. The CD56^dimSiglec-9⁺ NK cell subset is reduced in the peripheral blood of cancer patients.

(A and B) Expression of Siglec-9 on peripheral blood NK cells of healthy donors (n = 22) or patients with melanoma (n = 11) or CoACA (n = 10). Shown are frequency (A) and GMFI ratio of specific staining to isotype-matched control (B), with or without neuraminidase treatment. Lines within boxes denote 50th percentile; upper and lower margins of the boxes denote 25th and 75th percentile; whiskers denote 5th and 95th percentile. *P < 0.05, **P < 0.005, ***P < 0.001, Student’s t test.