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. 2014 Mar 3;124(4):1646–1659. doi: 10.1172/JCI71812

Figure 2. The GTPase pathway mediates DLC1’s role in breast cancer metastasis.

Figure 2

(A) Activation of Rho, CDC42, and their downstream effectors in cells with DLC1 KD and OE. (B) Effect of DLC1 on stress fiber formation. (C) Stress fiber density (n = 6). (D) WT DLC1 and R718E mutant OE in SCP2 cells. (E) The R718E mutant failed to inactivate Rho and CDC42. (F–H) In vivo bone metastasis analysis of the R718E mutant (n = 10 per group). Shown are representative BLI images and H&E staining (F), BLI quantitation (G), and animal survival (H). Scale bars: 10 μm (B); 50 μm (F). *P < 0.05, **P < 0.01.