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. 2014 Mar 10;124(4):1711–1722. doi: 10.1172/JCI72058

Figure 3. iNOS rapid induction in recruited phagocytes relies on the combined action of IFN-γ and TNF-α.

Figure 3

(A and B) C57BL/6 mice were infected with L. major. Two weeks later, a mixture of BMCs from CD45.1+ WT and Nos2–/–, Ifngr–/–, Myd88–/–, or Tnfr1–/– mice was injected in the infected recipients. Ear tissues were harvested 3 days later and analyzed by flow cytometry. (C) Frequency of iNOS-expressing cells in labeled mPhagocytes measured by flow cytometry. Each dot represents an individual ear; horizontal line represents average values. Numbers shown in flow cytometry profiles represent the percentage of cells falling into the indicated region. *P < 0.05; ***P < 0.001. Data are representative of 2 to 4 independent experiments.