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. 2014 Feb 24;124(4):1537–1551. doi: 10.1172/JCI45005

Figure 3. Increased protection of TNFRp75–/– mice during chronic M. tuberculosis infection.

Figure 3

WT and TNFRp75–/– mice were infected by aerosol inhalation with 50–100 CFU M. tuberculosis. (A and B) Survival was monitored (A; n = 10 per group; P < 0.0005, log-rank test), and pulmonary bacilli burdens were determined at the indicated time points by colony enumeration assay (B). (C) Bacilli burden in lung sections was confirmed by Ziehl-Neelsen staining. (D and E) Chronic inflammation was quantified at 4.5 months after infection (D) and confirmed by analysis of H&E-stained lungs sections at 4.5 and 7.5 months after infection (E). Original magnification, ×1,000 (C); ×40 (E). Values in B and D are mean ± SEM of 4 mice per group. Data are representative of 4 similar experiments (A) or 1 of 3 similar experiments (B–E). *P < 0.05, **P < 0.01, ANOVA.