Figure 4. Increased recruitment of activated DCs to the lungs of M. tuberculosis–infected TNFRp75^–/– mice.

WT and TNFRp75^–/– mice were infected at 50–100 CFU with M. tuberculosis. Lungs were harvested at 7, 14, and 21 days after infection, and CD11b⁺ versus CD11c⁺ cell distribution (A) and total number of CD11c⁺ (B), CD11c⁺MHCII⁺ (C), CD11c⁺CD80⁺ (D), and CD11c⁺CD86⁺ (E) cells was assessed by flow cytometry. Data (mean ± SEM of 4 mice per group) are representative of 1 of 2 similar experiments. *P < 0.05, **P < 0.01, ANOVA.