Skip to main content
. 2014 Feb 24;124(4):1537–1551. doi: 10.1172/JCI45005

Figure 6. M. tuberculosis induces TNFR shedding.

Figure 6

(A and B) WT and TNFRp75–/– BMDCs were infected with M. tuberculosis at an MOI of 5:1, and TNFRp75 surface expression (A) and soluble TNFRp55 (B) were measured. Data (mean ± SEM of quadruplicate experiments) are representative of 1 of 2 experiments. (C–E) WT, TNFRp75–/–, and TNFRp55–/– mice were infected with 50–100 CFU M. tuberculosis. Surface TNFRp75 (C) was measured by flow cytometry in BAL cells, and soluble TNFRp55 (D) and TNFRp75 (E) were measured in lung homogenates by ELISA. ND, not detectable. Data (mean ± SEM of 4–5 mice per group) are representative of 1 of 2 similar experiments. *P < 0.05, **P < 0.01, ANOVA.