Skip to main content
. Author manuscript; available in PMC: 2014 Apr 2.
Published in final edited form as: Cancer Cell. 2012 Oct 16;22(4):506–523. doi: 10.1016/j.ccr.2012.09.003

Figgure 2. MiR-29 family is co-regulated by HDAC3 and PRC2.

Figgure 2

(A) Vorinostat treatment for 48 hours dose-dependently increased primary and mature miR-29 expression levels in Jeko-1 and Ramos cells. (B) DZNep treatment for 48 hours downregulated EZH2 and SUZ12 in Jeko-1, Ramos and HBL2 Cells. (C) DZNep treatment for 48 hours dose-dependently increased primary and mature miR-29 expression in Jeko-1, Ramos and HBL2 Cells. (D) Knockdown of Myc or HDAC3 by siRNAs increased pri- and mature miR-29 expression levels in Mino, Jeko-1 and Ramos cells. mRNA and miRNA expression levels of cells treated with siCtrl were arbitrarily set as 1. (E) Knockdown of EZH2 and SUZ12 by their siRNAs increased miR-29a-c gene expression in Mino and Ramos cells. Results in A-E are means ± SD from at least 3 biological replicates. (See also Figure S2)