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Interlocked feedback loops that keep circadian time. Genetic architecture of the core and interlocked feedback loops of Drosophila (a) and mice (b). Gene, protein and regulatory element names are as defined in the text. Sinusoidal lines represent rhythmic mRNAs; arrows depict the synthesis, assembly and/or localization of clock proteins; blocked line denotes repression; gray background indicates events in the nucleus; white background indicates events in the cytoplasm.
