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Genotypes and allelic distribution of sodium channel mutations in 62 offspring obtained by microinjection of TALENs and a 4 kb targeting construct.
| Scn8a | Scn5a | Scn4a | # mice |
|---|---|---|---|
| +/+ | +/+ | +/+ | 33 |
|
| |||
| tar/+ | +/+ | +/+ | 3 |
| tar/− | +/+ | +/+ | 2 |
|
| |||
| +/− | +/+ | +/+ | 15 |
| +/− | +/− | +/+ | 3 |
|
| |||
| −/− | +/+ | +/+ | 2 |
| −/− | +/− | +/+ | 2 |
| −/− | +/− | +/− | 2 |
| 62 | |||
Tar, targeted mutations in the endogenous Scn8a locus; −, null alleles caused by small insertions and deletions; +, wildtype.
