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F36VMpl dimerization, and not Thrombopoietin, induces erythropoiesis in the absence of Erythropoietin. Transduced CD34+ cells were cultured in serum-free medium in the absence of erythropoietin, either with chemical inducer of dimerization or thrombopoietin (Tpo). Untransduced CD34+ cells were cultured in the presence of Tpo. Flow cytometry shows generation of erythroid cells (glycophorin A +) at day7. Abbreviations: CID, chemical inducer of dimerization; Tpo, thrombopoietin.
