F36VMpl dimerization induces a distinct gene expression profile. Transduced CD34+ cells were cultured in the presence of chemical inducer of dimerization (CID), thrombopoietin, Epo or no treatment. CD34+ GFP+ cells were isolated on day 7 for microarray. (A) Selected genes up-regulated >2-fold with CID. (
B) Numbers of genes differentially expressed in each condition compared with no treatment. (C) Network analysis of genes differentially expressed with CID. Abbreviations: CID, chemical inducer of dimerization; Epo, erythropoietin; Tpo, thrombopoietin