. Author manuscript; available in PMC: 2014 Apr 2.

Published in final edited form as: CNS Neurol Disord Drug Targets. 2012 Jun 1;11(4):469–481. doi: 10.2174/187152712800792866

Table 2.

The TH Gene and PD Susceptibility in GWAS and Joint Analysis

GWAS Data Set	Minor Allele Frequency		P-Value in Combined Dataset	Major Allele	Minor Allele
GWAS Data Set	Case	Control	P-Value in Combined Dataset	Major Allele	Minor Allele
*rs2070762*			0.87	A	G
HIHG	0.483	0.504
CIDR	0.494	0.497
NINDS	0.521	0.448
*rs6356*			0.84	T	C
HIHG	0.383	0.374
CIDR	0.360	0.353
NINDS	0.356	0.375
*rs10743152*			0.1	T	C
HIHG	0.401	0.384
CIDR	0.381	0.376
NINDS	0.386	0.314

Minor allele frequency of each TH SNP that has been examined in three GWAS, i.e. HIHG, CEDR and NINDS, were listed in cases and controls separately. The P value is generated using an additive model in the combined GWAS dataset of HIHG, CIDR, and NINDS. The Major and minor allele for each SNP is also listed.