. Author manuscript; available in PMC: 2014 Apr 2.

Published in final edited form as: CNS Neurol Disord Drug Targets. 2012 Jun 1;11(4):469–481. doi: 10.2174/187152712800792866

Table 3.

The TH Gene and PD Susceptibility in Candidate Gene Study

Study	Polymorphism	Description of Data Set			Results
Study	Polymorphism	Case	Control	Population	Results
Plante-Bordeneuve, 1994	HUMTH01	44	50	England	Negative
Kunugi, 1998	rs6356	99	161	Japan	Negative
Mizuta, 2006	rs2070762	190	190	Japan	Negative
Sutherland, 2008	HUMTH01, rs680 (IGF2), rs689 (INS)	215	215	Australia	Positive (mainly driven by rs680)
Punia, 2010	10 tagSNPs including rs6356	339	334	North India	Negative

Summary of candidate gene studies on the association between TH SNPs and PD susceptibility. The table lists the polymorphism(s) examined, number of cases and controls, countries where the study was carried out in each study. No study found a significant association between TH polymorphism and PD susceptibility.