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. Author manuscript; available in PMC: 2014 Apr 2.
Published in final edited form as: Nat Struct Mol Biol. 2013 Jan 13;20(2):230–236. doi: 10.1038/nsmb.2485

Figure 3.

Figure 3

Structural comparison of WT22Efv and RT–DNA–Nvp (3V81)29. (a) Pairwise comparisons of RT in the 3V81 structure with RT complexed with Nevirapine (3QIP14), an RT ternary complex (1RTD26), and our WT22Efv (4B3O). The Cα-Cα vector maps are shown after superposition of p51 subunits and colored as in Fig. 2. Domain movements of 3V81 relative to others are indicated by black arrowheads. (b) Comparison of the entire RT–DNA–Nvp complex (3V81) with an RT–DNA–dNTP ternary complex (3KK227). Upon superposition of the nucleic acids, both of which are crosslinked to p66 via Q258C, not only are the DNAs highly similar, but also are the RT proteins except for the p66 fingers and palm subdomains as indicated by the grey arrowhead. The protein and DNA are color coded as indicated, and the NNRTI (Nvp) is shown as purple spheres.