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. Author manuscript; available in PMC: 2014 Apr 2.
Published in final edited form as: Nat Struct Mol Biol. 2013 Jan 13;20(2):230–236. doi: 10.1038/nsmb.2485

Figure 4.

Figure 4

Structural comparison of nucleic acid complexed with RT. (a) Five previously reported RT–nucleic acid complexes (1RTD26, 1HYS30, 1T0552, 2HMI (uncrosslinked)38, and 3KJV27). The structures are shown after superposition of the p51 subunits. RT is shown as molecular surface with the fingers, palm, thumb, connection and RNase H domains color-coded blue, red, green, gold and magenta, respectively. The four DNA are depicted as orange template and yellow primer strands. The PPT RNA/DNA hybrid in 1HYS is shown in pink and blue. (b) Differences between the RNA/DNA hybrid in WT22Efv (red and yellow) and the PPT hybrid in 1HYS (pink and blue) after superposition of p51 subunits. (c) Comparison of the two hybrids and four DNAs (in light grey as in (a)). Red arrows highlight the main changes in WT22Efv.