Table 1. Mean phenothiazine-induced cytotoxicity across the lung cancer cell line panel.
Cell line |
Cytotoxicity (%) at 10 μM |
|||||||
---|---|---|---|---|---|---|---|---|
cisFPX | PZ | CPZ | TFPZ | FPZ | TFP | Mean | S.D. | |
SCLC | ||||||||
H69 | 43 | 19 | 82 | 61 | 58 | 57 | 53 | 21 |
H82 | 85 | 43 | 90 | 80 | 100 | 100 | 83 | 21 |
H592 | 59 | 40 | 63 | 59 | 69 | 57 | 58 | 10 |
U-1285 | 93 | 84 | 100 | 100 | 100 | 100 | 96 | 7 |
U-1568 | 20 | 22 | 40 | 30 | 14 | 15 | 24 | 10 |
U-1690 | 10 | 20 | 48 | 23 | 29 | 36 | 28 | 13 |
U-1906 | 50 | 50 | 95 | 93 | 76 | 74 | 73 | 20 |
U-2020 | 75 | 49 | 89 | 85 | 94 | 96 | 81 | 18 |
NSCLC | ||||||||
A549 | 25 | 0 | 12 | 0 | 6 | 2 | 8 | 10 |
H125 | 9 | 44 | 43 | 43 | 0 | 0 | 23 | 22 |
H1299 | 0 | 3 | 52 | 13 | 0 | 0 | 11 | 21 |
H157 | 44 | 25 | 30 | 33 | 37 | 44 | 36 | 8 |
H23 | 1 | 8 | 17 | 5 | 7 | 8 | 8 | 5 |
H661 | 20 | 21 | 29 | 13 | 19 | 10 | 19 | 7 |
U-1752 | 32 | 37 | 40 | 28 | 31 | 32 | 33 | 4 |
U-1810 | 28 | 14 | 23 | 9 | 20 | 9 | 17 | 8 |
The cytotoxicity values were calculated by the following formula: cytotoxicity=100%−viability (%), as analyzed by MTT assay