Figure 2.

Univariate analysis on the effects of p53 mutations on cancer patient survival. Each hotspot mutation was compared with nonsense mutation using Kaplan–Meier survival analysis, and the P-values are indicated on the graph. Significantly shorter survival was found in patients baring p53 mutations on residues R282 (a) and R248 (b), but not on R175, R273 (c), Y220, and G245 (d). No significant difference was found between nonsense/structural/contact mutations (e), or between nonsense/frameshift/missense mutations (f). The wild-type and mutated p53 (including hotspots) showed no significant difference for overall patient survival (g)