Figure 2.

Antitumor effects of individual compounds and M4 on the human lung cancer H460/TaxR in vivo. The mice received the treatments of individual compounds or M4 every day by subcutaneous injection for 11 days, or the treatment of paclitaxel every other day for three times as positive control. The experiment was terminated and the mice were killed on day 22. (a) Antitumor effects of individual compound at low dose or paclitaxel as positive control. (b) Antitumor effects of individual compounds or M4 at high dose. Each point refers to the mean value of 6–7 tumors. **, the value is significantly different from that of control (P<0.01). (c) Effects of paclitaxel or M4 on mice survival (Kaplan–Meier plot). (d) Effects of paclitaxel or M4 on the body weight of mice