Figure 7.

Individual compounds and M4 mediate the protein acetylation, Akt dephosphorylation and MAPK in H460/TaxR cells. (a) Time-dependent effect of compound alone or M4 on protein acetylation, the Akt and the MAPK signaling pathway. The cells were treated with 27 (1.0 μM), 107 (2.0 μM), 167 (2.0 μM), 254 (1.0 μM) or M4 (1.0 μM) for indicated periods, and the cell lysates were immunoblotted. (b) The scheme of the signal pathway involved in the anticancer activity of compound alone or M4. (c) A working model showing how the four compounds in M4 produce synergistic anticancer effect