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Deletion of Cav-1 induces a loss of HSC quiescence and accelerates cellular senescence. (a) FACS analysis of 7-AAD and Ki-67 staining of LSKs from Cav-1+/+ or Cav-1−/− mice. (b) The percentage of cells in each phase of the cell cycle. (c) FACS analysis of LSKs from Cav-1+/+ or Cav-1−/− mice using the ROS detection reagent. (d) The percentage of ROS-positive cells in the LSK population; n=5 mice per group. The results represent the mean±s.d. *P<0.05; **P<0.01
