Figure 4.

Pdr-1 mutation suppresses DTC migration defects in both hypomorphic ced-10 mutants. The gonads of ced-10(n3246) or ced-10(n1993) animals at the fourth larval stage (L4) with or without mutations in pdr-1 were scored for morphology using DIC microscopy (d, left and right, respectively). (a) Representative picture showing the normal U-shaped gonad in wild type, pdr-1 and a percentage of ced-10;pdr-1 animals. (b and c) Representative DIC pictures showing the abnormalities scored and analyzed as in (d). (d and e) Bar graph representing the scoring of DTC abnormalities in the two ced-10 backgrounds, ced-10(n3246) and ced-10(n1993), respectively. More than 50 gonad arms were scored for all genotypes. P-values derived using Fisher's exact test are shown