Table 1. pdr-1 mutations suppress the engulfment defects of engulfment ced-10 gene mutations.
| Genotype | Number of cell corpses±s.d. | n | P-value |
|---|---|---|---|
| N2 | 0±1 | 30 | — |
| pdr-1(tm395) | 0 | 30 | — |
| pdr-1(lg103) | 0±1 | 30 | — |
| ced-10(n3246) | 21.4±0.6 | 67 | — |
| ced-10(n1993) | 15.41±1.054 | 30 | — |
| ced-10(n1993);pdr-1(tm395) | 6.1±0.3 | 48 | <0.0001 to ced-10(n1993) |
| ced-10(n1993);pdr-1(lg103) | 7.4±0.4 | 30 | <0.0001 to ced-10(n1993) |
| ced-10(n3246);pdr-1(lg103) | 8.9±0.3 | 121 | <0.0001 to ced-10(n3246) |
| ced-10(n3246);pdr-1(tm395) | 10.5±0.7 | 35 | <0.0001 to ced-10(n3246) |
| pdr-1(lg103);byEx[PDR-1 wild type;sel-12::gfp] | 0±1 | 30 | — |
| ced-10(n3246);pdr-1(lg103);byEx[PDR-1 wild type;sel-12::gfp] | 19.48±0.5 | 63 | 0.0117 to ced-10(n3246) |
| ced-5(n1812)a | 25.07±0.8 | 30 | — |
| ced-5(n1812);pdr-1(lg103) | 19.05±0.7 | 31 | <0.0001 to ced-10(n3246) |
| ced-1(e1375)b | 16.7±0.5 | 31 | — |
| ced-1(e1375);pdr-1(lg103) | 9.9±0.6 | 51 | <0.0001 to ced-10(n1993) |
pdr-1 accelerates the engulfment process. First larval stage (L1) animals were anesthetized and viewed using DIC microscopy. Cell corpses were counted in the head of L1s. The P-value refers to comparisons between the strain with the engulfment mutation alone, ced-10(n3246), ced-10(n1993), ced-5(n1812), ced-1(n1375), and the strains with the engulfment mutation with either the pdr-1(tm395) or pdr-1(lg103) alleles or the rescue strain ced-10(n3246);pdr-1(lg103);byEx[PDR-1 wt::sel-12-gfp]. All data are means±s.d. (statistics: paired t-test; two-tailed, unequal variances)