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. 2014 Jan 17;42(6):4019–4030. doi: 10.1093/nar/gkt1387

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© The Author(s) 2014. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 4. — Hexamer and MEME analysis of SRSF10-regulated exon inclusion and exclusion. (A) The sum of the minus log2-transformed P-values of GA-rich hexamers within the five regions around regulated cassette exons was compared with control cassette exons that are not affected by SRSF10. The red line represents SRSF10-mediated exon inclusion compared with the control (left), and the blue line represents SRSF10-mediated exon exclusion compared with the control (right). There is no obvious peak in the upstream exon or the two flanking introns around the cassette exons. (B) A representative list of top GA-rich hexamers was shown for SRSF10-activated cassette exons, -activated downstream constitutive exons and -repressed downstream constitutive exons, respectively. FC is fold change, P-value stands for statistically significance of GA-rich hexamers between SRSF10-regulated group and controls and FDR indicates false discovery rate. Shown in brackets are the number of overrepresented GA-rich 6-mers and the percentage of exons containing at least one overrepresented 6-mer. (C) Potential GA-rich motifs derived from the aforementioned overrepresented GA-rich 6-mers using MEME (P < 0.0001).