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. 2014 Jan 6;42(6):3783–3791. doi: 10.1093/nar/gkt1327

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© The Author(s) 2014. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Binder exchange simulation data for (a) , (b) and (c) . At time , the DNA chain is saturated with binders (number of occupied sites ), and the concentration [shown in legend in (b)] is immediately applied to the system. In (a) the exchange is mostly diffusion-limited, and there is not a large difference on changing the binder concentration. In (b) and (c) exchange occurs at different rates depending on the external concentration c of untagged binders. Numerical calculation using the matrix k_ij in Equation (3) yields nearly quantitative matching, as shown in (d–f) [corresponding to (a–c), respectively]. The inset in (b) plots the normalized overall relaxation of the number of tagged and untagged binders as a function of time t in analogy to the main plot in (b). Colors correspond to concentrations in b and demonstrate a concentration-dependent approach to equilibrium () that is concomitant with the concentration-dependent exchange process.

Inline graphic — Binder exchange simulation data for (a) , (b) and (c) . At time , the DNA chain is saturated with binders (number of occupied sites ), and the concentration [shown in legend in (b)] is immediately applied to the system. In (a) the exchange is mostly diffusion-limited, and there is not a large difference on changing the binder concentration. In (b) and (c) exchange occurs at different rates depending on the external concentration c of untagged binders. Numerical calculation using the matrix k_ij in Equation (3) yields nearly quantitative matching, as shown in (d–f) [corresponding to (a–c), respectively]. The inset in (b) plots the normalized overall relaxation of the number of tagged and untagged binders as a function of time t in analogy to the main plot in (b). Colors correspond to concentrations in b and demonstrate a concentration-dependent approach to equilibrium () that is concomitant with the concentration-dependent exchange process.