Cover: 2014 – International Year of Crystallography. DNA and protein structures reproduced with permission from the following NAR articles:

Chen, Y., Zhang, X., Dantas Machado, A.C., Ding, Y., Chen, Z., Qin, P.Z., Rohs, R. and Chen, L. (2013) Structure of p53 binding to the BAX response element reveals DNA unwinding and compression to accommodate base-pair insertion. Nucleic Acids Res., 41, 8368–8376.

Eldar, A., Rozenberg, H., Diskin-Posner, Y., Rohs, R. and Shakked, Z. (2013) Structural studies of p53 inactivation by DNA-contact mutations and its rescue by suppressor mutations via alternative protein-DNA interactions. Nucleic Acids Res., 41, 8748–8759.

Zhang, F., Tsunoda, M., Suzuki, K., Kikuchi, Y., Wilkinson, O., Millington, C.L., Margison, G.P., Williams, D.M., Czarina Morishita, E. and Takenaka, A. (2013) Structures of DNA duplexes containing O6-carboxymethylguanine, a lesion associated with gastrointestinal cancer, reveal a mechanism for inducing pyrimidine transition mutations. Nucleic Acids Res., 41, 5524–5532.

Zouhir, S., Perchat, S., Nicaise, M., Perez, J., Guimaraes, B., Lereclus, D. and Nessler, S. (2013) Peptide-binding dependent conformational changes regulate the transcriptional activity of the quorum-sensor NprR. Nucleic Acids Res., 41, 7920–7933.