Table 2.
Genetic loci associated with differences in metabolite–metabolite correlations between obese and non-obese individuals. Candidate gene, potential candidate gene in the region; Chr, chromosome; Pos, SNP position in NCBI human genome build 36; p-value, p-value for association between locus and variation in correlation between XL-VLDL/M-VLDL. Significant associations between genetic variants and variation in association between pairs of metabolites were identified using genome-wide significance level threshold (p < 5 × 10−8/D; where D = 5).
| candidate gene | SNP | Chr | Pos | p-value |
|---|---|---|---|---|
| DOCK | rs1334806 | 1 | 62875313 | 1.32 × 10−09 |
| PPP1R12B | rs12743401 | 1 | 202476648 | 1.01 × 10−13 |
| OTOF | rs7592040 | 2 | 26741551 | 1.47 × 10−09 |
| ABHD5 | rs1078248 | 3 | 43794357 | 2.36 × 10−09 |
| GRIA1 | rs573496 | 5 | 152893433 | 1.94 × 10−09 |
| UST | rs2500542 | 6 | 149331204 | 7.95 × 10−10 |
| DLC1 | rs1454953 | 8 | 13315983 | 6.23 × 10−10 |
| DLC1 | rs7814428 | 8 | 13324439 | 2.37 × 10−10 |
| HEY1 | rs2920949 | 8 | 80869508 | 4.14 × 10−09 |
| FAM84B | rs7357357 | 8 | 127189138 | 4.49 × 10−09 |
| FAM84B | rs10094775 | 8 | 127197554 | 6.50 × 10−09 |
| FAM84B | rs4557669 | 8 | 127306602 | 1.97 × 10−09 |
| SH2D4B | rs10509433 | 10 | 83080528 | 2.00 × 10−10 |
| OR10A6 | rs17315588 | 11 | 7913911 | 3.99 × 10−10 |
| OR10A6 | rs1564632 | 11 | 7873288 | 3.23 × 10−09 |
| EED | rs9971532 | 11 | 85929490 | 1.72 × 10−09 |
| LDHB | rs1650307 | 12 | 21803770 | 3.11 × 10−09 |
| DACH1 | rs7981816 | 13 | 72642843 | 5.33 × 10−09 |
| NAGPA | rs2302553 | 16 | 5056295 | 3.06 × 10−09 |
| NAGPA | rs3815490 | 16 | 5060568 | 9.01 × 10−10 |
| ATP4A | rs8106239 | 19 | 36085358 | 9.14 × 10−10 |
| BPIFB3 | rs2093066 | 20 | 31652596 | 7.81 × 10−10 |
| BPIFB3 | rs378098 | 20 | 31660543 | 7.46 × 10−10 |
| MN1 | rs2040699 | 22 | 28042532 | 3.72 × 10−09 |