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Dependence of the exposure to bound drug 
on distance from the supply of drug at t = 72 h for three different binding affinities where the association rate constant only varies over the range: k2 = 4 × 10−7, k2 = 4 × 10−6 and k2 = 4 × 10−5 μM−1 s−1. The tri-exponential/IV bolus PK profile was used as input. (Online version in colour.)
