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Antiviral mechanisms of Mx proteins. Steps in the life cycles of different viruses that are inhibited by Mx proteins are shown. Human MxA, mouse Mx2, and porcine Mx1 inhibit Thogoto virus (THOV), vesicular stomatitis virus (VSV), La Crosse virus (LACV), and influenza viruses in the cytoplasm. Mouse Mx1 inhibits THOV and influenza viruses in the nucleus.
