Fig 5.

Amino acid residues in influenza A virus nucleoprotein associated with sensitivity to Mx. Left, 3D structure of an NP monomer (PDB file 2Q06 [145]). The residues important for Mx1 and MxA resistance are highlighted in red. Residues that contribute in only a minor way to Mx1 resistance are indicated in light red (95). Right, these important residues are also exposed on the surface of viral ribonucleoprotein (RNP) complexes (PDB file 4BBL [146]). The RNA strand is depicted in green. The images were generated with PyMOL.