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. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: J Neuroimmune Pharmacol. 2014 Feb 8;9(2):102–116. doi: 10.1007/s11481-013-9520-2

Figure 3. HIV-induced neuropathology is increased in brains from HIV patients over the age of 50. A.

Figure 3

MAP2 immunostaining shows neuronal atrophy and discontinuous processes during HIVE, and more so in HIVE brains over the age of 50. B. MAP2 signal intensity is decreased in HIVE brains compared to HIV brains in both age groups, but HIVE brains from patients over 50 years of age show the least MAP2 immunostaining. C. Viral load, as estimated by p24 levels, is decreased in brains of HIVE patients over the age of 50. D. CD68 immunostaining, representing activated infiltrating monocytes and microgia, is more robust in brains from HIVE patients and is the most intense in those over the age of 50. E. Astrogliosis is increased in brains of HIVE patients, with the most intense signal in brains from HIVE patients over the age of 50. *p<0.05 by unpaired student T test.