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. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: J Neuroimmune Pharmacol. 2014 Feb 8;9(2):102–116. doi: 10.1007/s11481-013-9520-2

Figure 5. FGF1 protects gp120 tg mouse model from neurodegeneration.

Figure 5

A. For this experiment GFAP-gp120 tg mice were crossed with PDGF-FGF1 mice. Brain dentate gyrus sections were labeled with the doublecortin for detection of neuroblasts. Non tg and FGF1 tg mice display abundant neurogenesis in the dentate gyrus of the hippomouse. Gp120 tg mice have decreased neurogenesis, but FGF1 overexpression in gp120 mice reverses this pathology. B. Total neuroblast numbers were statistically equivalent in non tg mouse brains from untreated and FGF1 tg mice. Total neuroblast numbers were decreased by 50% in gp120 tg mouse brains, and FGF1 overexpression recovered levels to near that of control. *#p<0.05 by One-way Anova with posthoc Fisher test.