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Transport of Gly-Sar, MPP+, and valacyclovir is significantly higher across normoxic calf SCRPE than hypoxic calf SCRPE. On the other hand, transport of phenylacetic acid is significantly higher across hypoxic SCRPE than normoxic SCRPE. Transport of all four transporter substrates was significantly inhibited in the presence of inhibitor cocktail. A) Gly-Sar; B) MPP+; C) Valacyclovir; and D) Phenylacetic acid. Data are expressed as mean ± SD for n =4.
