Table 1.

	Baseline (predose)	End of infusion	30 min after end of infusion	p- Value
Systolic blood pressure (mmHg)
N	113	113	111
Mean (±SD)	126 (20)	124 (19.3)	123 (16.7)
Range	92–210	93–216	92–181
N		113	111
% change from baseline (±SD)		−1.5 (7.0)	−2.2 (7.6)	0.322
Range		−21.1–18.8	−18.0–18.4
Diastolic blood pressure (mmHg)
N	113	113	111
Mean (±SD)	76 (10)	74 (11)	74 (11)
Range	51–106	48–104	50–103
N		113	111
% change from baseline (±SD)		−2.6 (8.5)	−2.6 (9.4)	0.837
Range		−26.2–20.8	−24.4–38.1
Heart rate (beats/min)
N	108	109	109
Mean (±SD)	68 (10)	68 (10)	66 (10)
Range	48–97	48–103	47–100
N		107	106
% change from baseline (±SD)		0.3 (8.3)	−2.6 (8.8)	0.004
Range		−27.8–24	−28.6–24.2

SD = standard deviation