Table 3. Susceptibility profile of P. aeruginosa PAOΔampR and PAOΔampC after SIC antibiotic exposure.
Results are shown as MIC values (µg ml−1).
| Class | Antibiotic | None* | None† | SIC antibiotic exposure | ||||||||||||
| IPM (0.1 µg ml−1) | MEM (0.05 µg ml−1) | CAZ (0.1 µg ml−1) | PIP (0.2 µg ml−1) | CIP (0.05 µg ml−1) | TOB (0.1 µg ml−1) | |||||||||||
| ampR | ampC | ampR | ampC | ampR | ampC | ampR | ampC | ampR | ampC | ampR | ampC | ampR | ampC | |||
| Penicillin | AMX | >256 | 12 | 12 | 12 | 12 | 12 | 12 | 12 | 12 | 8 | 24 | 8 | 6 | 12 | 16 |
| SAM | 96 | 12 | 16 | 3 | 12 | 8 | 8 | 6 | 16 | 8 | 32 | 6 | 6 | 4 | 24 | |
| TZP | (4) | 3 | 4 | 1 | 1.5 | 2 | 3 | 1.5 | 3 | 3/2 | 4 | 2 | 1.5 | 2 | 3 | |
| TIM | 24 | 24 | 48 | 8 | 16 | 6 | 12 | 4 | 16 | 8 | 24 | 4 | 6 | 6 | 12 | |
| Cephalosporin | CAZ | 1.5 | 1.5 | 2 | 0.38 | 1 | 1 | 1 | 1 | 1.5 | 1.5 | 2 | 1 | 0.75 | 1 | 1.5 |
| FEP | 2 | 1.5 | 2 | 0.5 | 1.5 | 1 | 0.75 | 0.75 | 1.5 | 1.5 | 3 | 1 | 1 | 2 | 3 | |
| Carbapenem | IPM | 1.5 | 0.38 | 0.5 | 0.38 | 0.38 | 0.38 | 0.25 | 0.38 | 0.25 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 |
| DOR | 0.38 | 0.25 | 0.125 | 0.25 | 0.125 | 0.19 | 0.064 | 0.25 | 0.094 | 0.25 | 0.19 | 0.38 | 0.064 | 0.5 | 0.125 | |
| MEM | 0.38 | 0.5 | 0.3 | 0.25 | 0.25 | 0.5 | 0.19 | 0.25 | 0.125 | 0.5 | 0.25 | 0.38 | 1 | 0.5 | 1.5 | |
| ETP | >32 | 6 | 8 | nd | nd | nd | nd | nd | nd | 8 | 8 | 6 | ND | 8 | ND | |
| Monobactam | ATM | 3 | 1.5 | 3 | 0.5 | 1.5 | 1.5 | 3 | 0.75 | 1.5 | 1.5 | 3 | 1 | 1 | 1 | 3 |
| Quinolone | CIP | 0.25 | 1.5 | 0.25 | 1.5 | 0.25 | 1.5 | 0.25 | 1.5 | 0.25 | 1.5 | 0.38 | 1.5 | 0.125 | 1.5 | 0.38 |
| LVX | 0.5 | 6 | 0.5 | 6 | 0.5 | 3 | 0.5 | 4 | 0.5 | 4 | 0.5 | 4 | 0.25 | 4 | 0.75 | |
| Aminoglycoside | AMK | 4 | 3 | 4 | 3 | 4 | 3 | 3 | 2 | 4 | 3 | 4 | 3 | 6 | 3 | 4 |
| TOB | 1 | 0.5 | 1 | 0.38 | 0.75 | 0.38 | 0.5 | 0.38 | 0.75 | 0.38 | 0.75 | 0.25 | 0.75 | 0.38 | 0.75 | |
nd, Not determined.
*PAO1 MIC values are from Table 1 for comparison.
†PAOΔampR and PAOΔampC with no antibiotic exposure.