Skip to main content
. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Rev Med Virol. 2013 Nov 14;24(1):55–70. doi: 10.1002/rmv.1773

Figure 2. Summary of the interaction between RSV, antibodies, FcγRs and the innate immune system.

Figure 2

In monocytic cells, the interaction between Abs and FcγRs has a neutralizing or a disease enhancing effect on RSV. FcγRIIIA+ NK cells are responsible for ADCC, induce higher amounts of cytokines in the presence of Abs and increased amounts of FcγRIIIA+ NK cells are observed in severe RSV infections. Profound activation of neutrophils and increased cytokine release against RSV are induced in the presence of RSV-specific Abs. B cells from RSV infected infants younger than 3 months of age express fewer somatic mutations compared to older individuals. The complement system is involved in the Ab-mediated induction of CD4+ T cells upon RSV infection.