Table 1. Expression of different types of FcγR on innate cells and B cells and its proposed effect in the immune response against pathogens.
Type | FcγRI | FcγRIIA | FcγRIIC | FcγRIIIA | FcγRIIIB | FcγRIIB |
---|---|---|---|---|---|---|
Expression | Monocyte Macrophage Dendritic cell Neutrophil Eosinophil Mast cell1 |
Monocyte Macrophage Dendritic cell Neutrophil Basophil Eosinophil |
NKcell | Monocyte Macrophage Dendritic cell NK cell Mast cell |
Neutrophil Eosinophil1 |
Monocyte Macrophage Dendritic cell Neutrophil Basophil Mast cell NK cell B cell |
Effect | Phagocytosis Cytokine release ADE2 Degranulation3 Complement activation4 |
Phagocytosis Cytokine release ADE2 ADCC5 |
Cytokine release ADCC5 6 |
Phagocytosis Cytokine release Cross-talk TLR-4 Complement activation4 ADCC5 |
Phagocytosis Chemoattractants Cross-talk TLR-4 Degranulation3 ADCC |
Reduced phagocytosis Reduced TLR sigaling Reduced proliferation Apoptosis7 |
Upon stimulation with IFN-γ;
Antibody-dependent enhancement of disease;
Mast cells;
In mice models;
Antibody-dependent cellular toxicity;
Interaction with FcγRIII;
B cells