Fig. 6.

Kit-mediated chemotaxis is inhibited by loss of WASP signaling or treatment with pertussis toxin. (A) Individual cell tracks, chemotactic indices, and cell speeds presented as in Fig. 3 for BMMC isolated from WASP^{−/ −} mice (top panel, n ≥ 60 for each quadrant) and (B) BMMC treated with pertussis toxin (PTx, bottom panel, n ≥ 100 for each quadrant) and exposed to a KL gradient. Both groups of cells exhibited random motility at all KL concentrations.