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. 2014 Apr 2;9(4):e93688. doi: 10.1371/journal.pone.0093688

Figure 4. DAMGO and herkinorin inhibit N-type voltage-gated calcium channels in rat sensory neurons.

Figure 4

N-type voltage-gated calcium currents were recorded from rat TG neurons 24–48 h after isolation. Maximal current amplitudes were observed at −10 mV. Control currents were recorded first in SES with 0.1% DMSO (Vehicle). Following bath application of DAMGO (1 μM, 5 min) currents were again recorded. Cells that responded to DAMGO were washed with SES (5 min) and currents were recorded again prior to bath application of herkinorin (10 μM, 5 min) and final current measurement. Representative single cell current-voltage curves (A), traces (C), and the extent of current inhibition (expressed as % inhibition) mean ± SEM of 10 cells (B).