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. 2014 Apr 2;9(4):e93473. doi: 10.1371/journal.pone.0093473

Figure 1. Positive inotropic effect of apelin mediated through PKC. A.

Figure 1

Effect of apelin (Apelin-16 2 nmol/L) and Bis (90 nmol/L) on developed tension in isolated perfused, paced rat hearts. After a control period vehicle or drugs were infused for 20 minutes. Results are expressed as a percent change vs. baseline values. Data are mean ± SEM (n = 5). ***p<0.001 vs. vehicle control, †p<0.05 vs. apelin by repeated measures ANOVA and Bonferroni post-hoc test. B. Representative Western blot detection of translocation of PKCε and α isoforms from the soluble (S) to the particulate (P) fraction of left ventricular proteins in apelin treated and control animals.