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. 2014 Apr 2;9(4):e93489. doi: 10.1371/journal.pone.0093489

Figure 7. A model of the four mechanisms that contribute to the resistance to α-amanitin in concert.

Figure 7

The bicyclic octapeptide α-amanitin is shown as a red 8. Cuticular proteins block some of the α-amanitin from entering the cells (blockage). α-Amanitin that entered the cytoplasm is either sequestered in lipid particles, cleaved by peptidases, or detoxified by phase I and II detoxification enzymes, possibly followed by excretion.