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. 2014 Apr 2;9(4):e93788. doi: 10.1371/journal.pone.0093788

Figure 3. SOCS3 and insulin receptor phosphorylation on tyrosine 960 are reduced by IGFBP-3 NB injection.

Figure 3

For all studies, groups are control (ctrl), diabetic (Diabetic), Diabetic +IGFBP-3 NB (Diab +BP3), Diabetic +CMV (Diab+CMV), Diabetic+IGFBP-3 NB left eye (Diab+BP3 contra) and Diabetic+CMV left eye (Diab+CMV Contra). Panel A shows that SOCS3 levels are decreased after IGFBP-3, measured by Western blotting. Panel B shows that IRTyr960 phosphorylation is reduced, which follows the SOCS3 data since IRTyr960 is activated by SOCS3. *P<0.05 vs ctrl. #P<0.05 vs. Diabetic only, $P<0.05 vs. Diab+BP3. N = 5 for all groups. Data are mean ± SEM.