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. 2014 Apr 2;9(4):e93513. doi: 10.1371/journal.pone.0093513

Figure 5. Mizoribine attenuates aldosterone-induced upregulation of serum/glucocorticoid-regulated kinase and α epithelial sodium channels.

Figure 5

Western blot analysis for serum/glucocorticoid-regulated kinase (SGK), with-no-lysine 4 (WNK4), α epithelial sodium channel (αENaC), and α-tubulin was performed. The total cell lysate was prepared from the renal cortex of rats. Aldosterone (ALD) increased the expression of SGK and αENaC, and decreased the expression of WNK4, whereas mizoribine (MZR) attenuated these alterations. Graphs show the expression level quantified by densitometry and normalized with α-tubulin. Values are presented as mean ± SEM. *P<0.05.